DMD 30213 1 Absorption , distribution and biliary excretion of cafestol , a potent cholesterol elevating compound in unfiltered coffees in mice
نویسنده
چکیده
Division of Human Nutrition; Wageningen University, Wageningen, The Netherlands (SvC, GH, MB, RW) Nutrigenomics consortium, Top Institute of Food and Nutrition; Wageningen, The Netherlands(SvC, GH, MB) AMC Liver Center, Academic Medical Center, Amsterdam, The Netherlands (DRdW, CK,ROE) Institute of Health Sciences, VU University Amsterdam, The Netherlands (MK) TNO Quality of Life, Zeist, The Netherlands (RW) DMD Fast Forward. Published on January 4, 2010 as doi:10.1124/dmd.109.030213
منابع مشابه
Absorption, distribution, and biliary excretion of cafestol, a potent cholesterol-elevating compound in unfiltered coffees, in mice.
Cafestol is a diterpene present in unfiltered coffees. It is the most potent cholesterol-elevating compound present in the human diet. However, the precise mechanisms underlying this effect are still unclear. In contrast, cafestol is also known as a hepatoprotective compound, which is likely to be related to the induction of glutathione biosynthesis and conjugation. In the present study, we inv...
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Cafestol, a diterpene present in unfiltered coffee brews such as Scandinavian boiled, Turkish, and cafetière coffee, is the most potent cholesterol-elevating compound known in the human diet. Several genes involved in cholesterol homeostasis have previously been shown to be targets of cafestol, including cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid biosynthesis...
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The diterpenes cafestol and kahweol are present in unfiltered coffee in oil droplets and floating fines. They elevate serum cholesterol and alanine aminotransferase (ALT). We measured fines in coffee brews, and examined diterpene availability from spent grounds in healthy volunteers. Turkish or Scandinavian boiled coffee contained 2-5 g fines/L and French press coffee contained 1.5 g fines/L. A...
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Cafestol, a diterpene present in unfiltered coffee, potently increases serum cholesterol levels in humans. So far, no suitable animal model has been found to study the biochemical background of this effect. We determined the effect of cafestol on serum cholesterol and triglycerides in different mouse strains and subsequently studied its mechanism of action in apolipoprotein (apo) E*3-Leiden tra...
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Cafestol, a diterpene present in unfiltered coffee, potently increases serum cholesterol levels in humans. So far, no suitable animal model has been found to study the biochemical background of this effect. We determined the effect of cafestol on serum cholesterol and triglycerides in different mouse strains and subsequently studied its mechanism of action in apolipoprotein (apo) E*3-Leiden tra...
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